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Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators
- Source :
- MedChemComm. 7:1209-1216
- Publication Year :
- 2016
- Publisher :
- Royal Society of Chemistry (RSC), 2016.
-
Abstract
- Metabolic syndrome (MetS) is a widespread, complex disease cluster which consists of hypertension, atherosclerosis, dyslipidaemia and type II diabetes. The treatment of MetS requires multiple pharmaceutical agents leading to complex polypharmacy. Multi-target compounds might reduce the number of required drugs in MetS patients. In this study we fused three different pharmacophores of soluble epoxide hydrolase (sEH) inhibitors and peroxisome proliferator-activated receptor (PPAR) agonists. The most promising fused scaffold exhibits multi-target activity and represents a valuable starting point for design and evaluation of fused sEH/PPAR modulators.
- Subjects :
- 0301 basic medicine
Pharmacology
chemistry.chemical_classification
Epoxide hydrolase 2
Organic Chemistry
Complex disease
Pharmaceutical Science
Peroxisome proliferator-activated receptor
Peroxisome
medicine.disease
Biochemistry
Type ii diabetes
03 medical and health sciences
030104 developmental biology
chemistry
Drug Discovery
medicine
Molecular Medicine
Metabolic syndrome
Pharmacophore
Receptor
Subjects
Details
- ISSN :
- 20402511 and 20402503
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- MedChemComm
- Accession number :
- edsair.doi...........7fab54bf19237bb858ca099108164499