Sulfur Nanoparticle as an Effective HEK-293 Anticancer Agent

The preparation of sulfur nanoparticles (S-NPs) by a fast precipitation low-temperature approach using hydrochloric acid, sodium thiosulfate, and tetrabutylammonium bromide (TOAB) as a surfactant and stabilized has been reported in this work. The atomic content and purity of the S-NPs were supported by Energy Dispersive X-ray (EDX), and scanning electron microscopy (SEM) imaging supported the morphology and demonstrated nanoparticle aggregation. The progress of S-NPs preparation was monitored via UV-vis and optical activities behavior. The structure and the size of S-NPs were examined via powder X-Ray diffraction (PXRD) analysis. Transmission electron microscope (TEM) conforms the prepared S-NPs are in homogenous nano-sized with a value of 7-10 nm. The thermal stability of the desired S-NPs matrix was also determined by TG/DTG measurements. S-NPs' in vitro cytotoxic activities were evaluated against the HL-60 acute myeloid leukemia cell line, the HEK-293 kidney carcinoma cell line, and the HT-29 colon cancer cell line. The cytotoxicity of HEK-293 cell lines treated with S-NPs was higher than that of the other cell lines, according to the MTT assay.
Moroccan Journal of Chemistry, Vol. 11, No 2 (2023): In progress