ChemInform Abstract: Synthesis of 18-Demethyltaxoid via Stereoselective Allylation and Intramolecular Aldol Condensation Reactions

Authors :: Isamu Shiina
Teruaki Mukaiyama
Hayato Iwadare
Hiroki Sakoh
Hidehiro Arai
Source :: ChemInform. 31
Publication Year :: 2010
Publisher :: Wiley, 2010.
Abstract: Optically active novel 18-demethyltaxiods were successfully synthesized from 2α,10β-dibenzyloxy-11β-(t-butyldimethylsiloxy)-7β-hydroxy-1α-(p-methoxybenzyloxy)-8β,15,15-trimethyl-4-methylene-trans-bicyclo[6.4.0]dodecan-9-one (2) which corresponds to the BC ring system of Taxol by stereoselective allylation and intramolecular aldol condensation reactions.

Subjects :: Stereochemistry
Chemistry
Intramolecular force
Stereoselectivity
Aldol condensation
General Medicine
Optically active
Ring (chemistry)

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