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Keeping warm one cell at a time
- Source :
- Science. 373:292.3-293
- Publication Year :
- 2021
- Publisher :
- American Association for the Advancement of Science (AAAS), 2021.
-
Abstract
- Cell Biology Adipose thermogenesis is a conserved response to environmental cold or dietary excess and is classically triggered by ligand-dependent receptor activation. Johansen et al. report that cold regulation of Gs-coupled receptor expression represents a parallel point of control. Gpr3 turns out to be the most cold-induced Gs-coupled receptor in both brown and beige thermogenic adipose tissues. GPR3 has high basal Gs-coupled activity in the absence of an exogenous ligand. Mimicking the cold induction of Gpr3 triggered cAMP production, activated the thermogenic response, and counteracted metabolic disease in mice. A disease-associated genetic variant in GPR3 in patient-derived adipocytes revealed that GPR3 also acts as a regulator of human thermogenic adipose tissue. Targeting GPR3 could thus enable therapeutic stimulation of thermogenic adipose tissue in metabolic disease. Cell 184 , 3502 (2021).
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 373
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi...........7d8f0028ea387d2dbd268b2cd0c99a1a
- Full Text :
- https://doi.org/10.1126/science.373.6552.292-c