The Protective Effect of Erdostein on Renal Injury in Diabetic Rats

OBJECTiVES: Oxidative stress plays a role in the pathogenesis of diabetic nephropathy. It has been reported in many studies that antioxidant therapy may decrease complications related to diabetes mellitus. We aimed to evaluate the protective effects of erdostein on diabetic renal injury in diabetic rats. maTERial and mETHOdS: Thirty rats were randomly divided into 5 experimental groups (Group 1: control, group 2: erdostein, group 3: alloxan, group 4: alloxan+erdostein, and group 5: alloxan+insulin, n=6 each). Rats were made diabetic using alloxan injection intraperiteonally. Erdostein (10 mg/kg/day) orally and insulin two times a day (3 g/kg) intraperitoneally were administered for four weeks. All rats were then sacrificed and kidney histopathological examinations were performed by light microscopy. RESulTS: The diabetic rats had diabetic nephropathic changes in the kidney on histological examination but the rats treated with erdostein showed significantly less histopathological changes, similar to the control group compared with the diabetic rats not treated with erdostein (p 0.05). COnCluSiOn: Based on the present data, we conclude that erdostein may show protective effects on renal injury due to diabetes mellitus. KEY WORdS: Diabetic nephropathy, Erdostein, Renal failure, Alloxan Yazisma Adresi: Faruk TuRGuT Fatih Universitesi Tip Fakultesi, Nefroloji Bilim Dali, Ankara, Turkiye Gsm : 0 505 642 17 12 E-posta : turgutfaruk@yahoo.com Gelis Tarihi : 07.06.2010 Kabul Tarihi : 25.08.2010 Faruk TuRGuT1 ayse CaRliOglu2 Rabia alKan3 derya aKdEnIz3 Hacer HalTas4 ozlem saHIn BalCiK5 Ebru uz1 omer Faruk KaRaTas6 1 Fatih Universitesi Tip Fakultesi, Nefroloji Bilim Dali, Ankara, Turkiye 2 Fatih Universitesi Tip Fakultesi, Endokrinoloji Bilim Dali, Ankara, Turkiye 3 Fatih Universitesi Tip Fakultesi, Ic Hastaliklari Anabilim Dali, Ankara, Turkiye 4 Fatih Universitesi Tip Fakultesi, Patoloji Anabilim Dali, Ankara, Turkiye 5 Fatih Universitesi Tip Fakultesi, Hematoloji Bilim Dali, Ankara, Turkiye 6 Fatih Universitesi Tip Fakultesi, Uroloji Anabilim Dali, Ankara, Turkiye Turgut F ve ark: Diyabetik Nefropatide Erdostein Etkisi Cilt/Vol: 19, No: 3, 2010, Sayfa/Page: 157-161 158 Turk nefroloji diyaliz ve Transplantasyon dergisi Turkish Nephrology, Dialysis and Transplantation Journal