HEMOPHILIA: PREVENTION AND TREATMENT OF BLEEDING WITH OVARIAN EXTRACT

Following the announcement by Carroll L. Birch 1 of the discovery that a hormonal disturbance exists in hemophilia which is temporarily relieved by parenteral administration of ovarian substances, the opportunity presented itself to us in a case of that disease to test the efficacy of ovarian extract for controlling dangerous spontaneous bleeding and to gather data of possible future assistance for safeguarding against persistently bleeding hemophiliac patients who need surgical operations. The potential value to surgery of such clinical applications of Birch's discovery is obvious. The data from this case are reported without waiting for more material, since the disease is uncommon 2 and prompt standardization of the surgical methods will require that data from many sources be pooled in the literature. Birch gave daily injections of ovarian extract for eight months to one person with hemophilia and abolished the abnormal tendency to bleeding during that period and for two