The serum α1-antitrypsin in families with hypo-α1-antitrypsinemia

The serum content of α1-antitrypsin was estimated with immunoprecipitation in tubes utilizing a specific antiserum. The results agreed with those obtained in association with the determination of the total antitryptic activity of serum in members of families with hypo-α1-antitrypsinemia. No overlapping occurred between normals, hetero- and homozygotes. The non-α1-antitrypsins of 1 ml serum inhibited in the average 0.15 mg trypsin.