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Metal-Free Radical-Triggered Selenosulfonation of 1,7-Enynes for the Rapid Synthesis of 3,4-Dihydroquinolin-2(1H)-ones in Batch and Flow
Metal-Free Radical-Triggered Selenosulfonation of 1,7-Enynes for the Rapid Synthesis of 3,4-Dihydroquinolin-2(1H)-ones in Batch and Flow
- Source :
- Advanced Synthesis & Catalysis. 359:4332-4339
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- A novel three-component selenosulfonation of 1,7-enynes with sulfinic acids and diphenyl diselenides for the formation of multifunctional 3,4-dihydroquinolin-2(1H)-ones was developed in batch and flow. This room-temperature protocol provides a highly efficient approach to diverse selenosulfones in moderate to excellent yields and with a broad scope of substrates. It should provide a potential synthesis method for the construction of diverse and meaningful 3,4-dihydroquinolin-2(1H)-ones derivatives in the fields of pharmaceutical and biological chemistry. Additionally, obvious acceleration (20h to 43s) was obtained under micro flow conditions.
Details
- ISSN :
- 16154150
- Volume :
- 359
- Database :
- OpenAIRE
- Journal :
- Advanced Synthesis & Catalysis
- Accession number :
- edsair.doi...........7cd3780d0900f590b83495912b0b7305
- Full Text :
- https://doi.org/10.1002/adsc.201701118