ChemInform Abstract: Anti-Histaminic Activity of Bromopyrrole Alkaloids Isolated from Caribbean Agelas Sponges

Four Caribbean Agelas sponges ( A. clathrodes, A. conifera, A. dispar, A. longissima ) have been investigated for the alkaloid composition. Along with a series of known bromopyrrole alkaloids, two related novel compounds of this class, dispacamides C ( 7 ) and D ( 8 ), were found and their structures determined with spectroscopic methods. All the isolated Agelas bromopyrrole alkaloids have been evaluated for the antihistaminic activity on the guinea pig ileum.