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Flow-injection pulse amperometric detection based on ion transfer across a water-plasticized polymeric membrane interface for the determination of imipramine
- Source :
- Sensors and Actuators B: Chemical. 122:369-374
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- A flow-injection pulse amperometric method for determining imipramine, based on ion transfer across a plasticized poly(vinyl chloride) (PVC) membrane, was developed. A four-electrode potentiostat with ohmic drop compensation was used, while a flow-through cell incorporated the four electrodes and the membrane, which contained tetrabutylammonium tetraphenylborate. The influence of the applied potential, the flow-injection variables and of the pH on the determination of imipramine was studied. In the selected conditions, a linear relationship between current peak height and imipramine concentration over a range of 1 × 10 −6 to 8 × 10 −5 M imipramine was found. Good repeatability and between-day reproducibility were obtained. No interference was observed on the part of some common ions and pharmaceutical excipients. The method proposed was applied satisfactorily to the determination of imipramine in pharmaceuticals and human serum.
- Subjects :
- Flow injection analysis
Chromatography
Tetraphenylborate
Metals and Alloys
Analytical chemistry
Condensed Matter Physics
Imipramine
Vinyl chloride
Amperometry
Potentiostat
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
chemistry.chemical_compound
Membrane
chemistry
Electrode
Materials Chemistry
medicine
Electrical and Electronic Engineering
Instrumentation
medicine.drug
Subjects
Details
- ISSN :
- 09254005
- Volume :
- 122
- Database :
- OpenAIRE
- Journal :
- Sensors and Actuators B: Chemical
- Accession number :
- edsair.doi...........7cb9fc9bbd1912082c9fc405446c3218