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Immune tolerance induction in patients with severe hemophilia with inhibitors: expert panel views and recommendations for clinical practice
- Source :
- European Journal of Haematology. 88:371-379
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- For hemophilia patients with inhibitors, immune tolerance induction (ITI) may help to restore clinical response to factor (F) VIII or FIX concentrates. Several ITI regimens and protocols exist; however, despite 30 yr of progressive investigation, the ITI evidence base relies mainly on observational data. Expert opinion, experience, and interpretation of the available evidence are therefore valuable to support clinical decision-making. At the Sixth Zurich Haemophilia Forum, an expert panel considered recent data and consensus to distill key practice points relating to ITI. The panel supported current recommendations that, where feasible, ITI should be offered early to children and adults (ideally ≤ 5 yr of inhibitor detection) when inhibitor titers are
- Subjects :
- medicine.medical_specialty
Hematology
medicine.diagnostic_test
business.industry
MEDLINE
General Medicine
030204 cardiovascular system & hematology
Bethesda unit
Haemophilia
medicine.disease
3. Good health
Surgery
Immune tolerance
03 medical and health sciences
0302 clinical medicine
Internal medicine
Medicine
Observational study
business
Intensive care medicine
030215 immunology
Genetic testing
Factor IX
medicine.drug
Subjects
Details
- ISSN :
- 09024441
- Volume :
- 88
- Database :
- OpenAIRE
- Journal :
- European Journal of Haematology
- Accession number :
- edsair.doi...........7c950f45bd11b257a7c63c8d9b4010cd