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The effect of sonochemical pretreatment on the enantioselectivity of Pt/Al2O3–cinchonidine-catalyzed ethyl pyruvate hydrogenation was studied at different hydrogen pressures in various solvents, mainly in acetic acid. The sonochemical pretreatment of a commercial Pt/Al2O3–cinchonidine catalytic system in acetic acid resulted in enhanced enantioselectivity providing excellent ee values (97% ee) under mild and widely varied experimental conditions. Moreover, the application of ultrasonics provides a possibility of the catalyst recycling without regeneration. The catalyst was tested by transmission electron microscopy to determine the effect of the sonication on the metal particle size morphology.