TH-D-304A-01: Development of Multi-Parametric Molecular Imager by Integrating Overhauser-Enhanced MRI (OMRI) with Prepolarized MRI (PMRI)

Purpose: To develop a multi‐parametric molecular imager to assess tumor hypoxia and redox status by integrating Overhauser‐enhanced MRI (OMRI) with prepolarized MRI (PMRI). Method and Materials: PMRI system acquires anatomic MR images comparable to conventional MRI. With a moderate hardware augmentation of the PMRI, we implemented field‐cycled OMRI and obtained electron paramagnetic resonance(EPR)images of nitroxide spin probes. Phantoms were made of 2‐cc tubes filled with pure water