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Z-Gln(Trt)-Aib-Aib-Aib-OMe synthesis using UNCA and BOP/PyBroP coupling methods

Authors :
Catherine Auvin-Guette
Sylvie Rebuffat
Patrick Jouin
Jacques Coste
Bernard Bodo
Eric Frérot
Source :
Tetrahedron Letters. 34:2481-2482
Publication Year :
1993
Publisher :
Elsevier BV, 1993.

Abstract

The steric hindered Aib-Aib-Aib tripeptide was synthesized in mild conditions, using PyBroP for the coupling of two Aib and Fmoc-Aib-NCA for the generation of the tripeptide, which was obtained with an excellent yield in THF. The coupling of Gln was carried out in the presence of BOP.

Subjects

Subjects :
Coupling (electronics)
Steric effects
Chemistry
Stereochemistry
Organic Chemistry
Drug Discovery
Tripeptide
Biochemistry

Details

ISSN :
00404039
Volume :
34
Database :
OpenAIRE
Journal :
Tetrahedron Letters
Accession number :
edsair.doi...........7bc7adedf56e954649cf73051d544bcb
Full Text :
https://doi.org/10.1016/s0040-4039(00)60446-x
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