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Function of androgen receptor in gene regulations
- Source :
- The Journal of Steroid Biochemistry and Molecular Biology. :627-633
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- Most of the androgen actions are considered to be mediated by the androgen receptor (AR) of the target genes. The AR is composed of a fairly large molecule because of the long A/B domains of its N-terminal. However, the independent roles of the AR as well as those of the estrogen receptors largely remained unknown mainly due to the lack of the AR knockout (ARKO) mice line. We have succeeded in generating the ARKO mouse by means of a conditional targeting using the Cre/loxP system. The ARKO males grew healthily although they showed a typical feature of the testicular feminization mutation (Tfm) and the hormonal assay revealed significantly lower serum androgen and higher LH levels in comparison with those of the wild type (WT) males. The serum estrogen levels were, however, comparable between both the ARKO and the WT. Another hallmark of the ARKO males was a state of high bone turnover osteopenia, in which the acceleration in the bone resorption clearly exceeded the bone formation. Male-typical behaviors were disrupted in male ARKO mice. Aiming at a quick differentiation of an androgen-dependent polyQ disease such as Kennedy's disease, the authors also developed the Drosophila fly-eye model in which the wild type and the polyQ-expanded human AR (hAR) was induced in the eyes of Drosophila. When androgen was administered to the flies induced with the polyQ-expanded hAR, their optical nerves were devastated.
- Subjects :
- Testicular feminization
medicine.medical_specialty
Ratón
medicine.drug_class
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Wild type
Estrogen receptor
Cell Biology
Biology
Androgen
Biochemistry
Bone resorption
Bone remodeling
Androgen receptor
Endocrinology
Internal medicine
medicine
Molecular Medicine
Molecular Biology
Subjects
Details
- ISSN :
- 09600760
- Database :
- OpenAIRE
- Journal :
- The Journal of Steroid Biochemistry and Molecular Biology
- Accession number :
- edsair.doi...........7b9dc73b43d26a156996e3db8cdee4b7