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Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient
- Source :
- Transplant Infectious Disease. 4:201-206
- Publication Year :
- 2002
- Publisher :
- Wiley, 2002.
-
Abstract
- A 20-year-old patient, who received a bone marrow transplant in order to treat metachromatic leukodystrophy (MLD), succumbed to cytomegalovirus (CMV) encephalitis. After CMV viremia developed, the patient received ganciclovir, but he was switched to foscarnet when ganciclovir resistance was suspected. Foscarnet was discontinued because of concern about its potential central nervous system toxicity. Autopsy samples of brain and cerebrospinal fluid contained CMV DNA with a UL97 mutation (M460V) known to confer ganciclovir resistance. No foscarnet resistance mutations were found.
- Subjects :
- Ganciclovir
Human cytomegalovirus
Foscarnet
Transplantation
business.industry
Congenital cytomegalovirus infection
virus diseases
biochemical phenomena, metabolism, and nutrition
medicine.disease
Virology
Metachromatic leukodystrophy
Infectious Diseases
medicine.anatomical_structure
Immunology
medicine
Bone marrow
business
Encephalitis
medicine.drug
Subjects
Details
- ISSN :
- 13982273
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Transplant Infectious Disease
- Accession number :
- edsair.doi...........7b29cde025cae23838fa617f7a057351