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Role of reactive metabolites of oxygen and nitrogen in inflammatory bowel disease 1,2 1This article is part of a series of reviews on 'Reactive Oxygen and Nitrogen in Inflammation.' The full list of papers may be found on the homepage of the journal. 2Guest Editor: Giuseppe Poli
- Source :
- Free Radical Biology and Medicine. 33:311-322
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- The inflammatory bowel diseases (IBD; Crohn's disease, ulcerative colitis) are a collection of chronic idiopathic inflammatory disorders of the intestine and/or colon. Although the pathophysiology of IBD is not known with certainty, a growing body of experimental and clinical data suggests that chronic gut inflammation may result from a dysregulated immune response to normal bacterial antigens. This uncontrolled immune system activation results in the sustained overproduction of reactive metabolites of oxygen and nitrogen. It is thought that some of the intestinal and/or colonic injury and dysfunction observed in IBD is due to elaboration of these reactive species. This review summarizes the current state-of-knowledge of the role of reactive oxygen species and nitric oxide in the pathophysiology of IBD.
- Subjects :
- chemistry.chemical_classification
Reactive oxygen species
Crohn's disease
Inflammation
medicine.disease
Biochemistry
Inflammatory bowel disease
Ulcerative colitis
digestive system diseases
Nitric oxide
chemistry.chemical_compound
Immune system
chemistry
Physiology (medical)
Immunology
medicine
Bacterial antigen
medicine.symptom
Subjects
Details
- ISSN :
- 08915849
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Free Radical Biology and Medicine
- Accession number :
- edsair.doi...........7b04feac72b31fe8065368dd56492859