Targeted cancer cell inhibition using multifunctional dendrimer-entrapped gold nanoparticles

Authors :: Su He Wang
James R. Baker
Guixiang Zhang
Mingwu Shen
Jingyi Zhu
Xisui Chen
Linfeng Zheng
Xiangyang Shi
Source :: MedChemComm. 4:1001
Publication Year :: 2013
Publisher :: Royal Society of Chemistry (RSC), 2013.
Abstract: Generation 5-poly(amidoamine) dendrimers pre-modified with folic acid and methotrexate (G5-FA-MTX) were used as templates for the synthesis of dendrimer-entrapped gold nanoparticles (Au DENPs). The synthesized [(Au0)50-G5-FA-MTX] DENPs were able to target and specifically inhibit the growth of cancer cells overexpressing high affinity folic acid receptors.

Subjects :: Pharmacology
Chemistry
Organic Chemistry
Amidoamine
Pharmaceutical Science
Biochemistry
chemistry.chemical_compound
Folic acid
Colloidal gold
Dendrimer
Drug Discovery
Cancer cell
medicine
Molecular Medicine
Methotrexate
Receptor
medicine.drug

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