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Modulatory Effects of Curcumin on Redox Status, Mitochondrial Function, and Caspace-3 Expression During Atrazin-Induced Toxicity
- Source :
- Journal of Biochemical and Molecular Toxicology. 28:378-385
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- Atrazin is currently the most widely used herbicide in agriculture with lots of adverse effects on human health. Curcumin is a polyphenol known for its antioxidant, anti-inflammatory, and anticancer properties. In the present study, the protective effect of curcumin on atrazin-intoxicated rats is evaluated. Toxicity was induced by oral administration of atrazine (400 mg/kg/day) for 3 weeks. Curcumin at a dose of 400 mg/kg/day was given simultaneously by oral route. Redox status, mitochondrial function, 8-hydroxydeoxyguanosine (8-OHdG) level by immunoassay, and caspace-3 expression by immunohistochemistry were evaluated. Curcumin showed significant cardiac protection with improvement of redox status, mitochondrial function, 8-OHdG level, caspase-3 immunoreactivity, and cardiac muscle degeneration. From this current study, it can be concluded that administration of curcumin improved atrazine-induced cardiotoxicity through its modulatory effect on redox status, mitochondrial function, and caspase-3 expression.
- Subjects :
- Cardiotoxicity
Antioxidant
Health, Toxicology and Mutagenesis
medicine.medical_treatment
General Medicine
Pharmacology
Mitochondrion
Toxicology
medicine.disease_cause
Biochemistry
Lipid peroxidation
chemistry.chemical_compound
chemistry
Oral administration
Toxicity
medicine
Curcumin
Molecular Medicine
Molecular Biology
Oxidative stress
Subjects
Details
- ISSN :
- 10956670
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Biochemical and Molecular Toxicology
- Accession number :
- edsair.doi...........7ac5a1fb78074d98b4d3d6773bc69cf3