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A Practical, Laboratory-Scale Synthesis of Perampanel
- Source :
- Synthesis. 44:57-62
- Publication Year :
- 2011
- Publisher :
- Georg Thieme Verlag KG, 2011.
-
Abstract
- The orally active, noncompetitive, selective AMPA receptor antagonist Perampanel, 2-[1′,6′-dihydro-6′-oxo-1-phenyl-(2′,3′-bipyridin)-5′-yl]benzonitrile, has been prepared from readily available, relatively inexpensive starting materials. The synthesis was carried out on a laboratory scale with no specialized equipment, and involved only two chromatographic purifications.
Details
- ISSN :
- 1437210X and 00397881
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Synthesis
- Accession number :
- edsair.doi...........7aa79a837834eb76c940b7439a0835b0