Electrophilic addition to o-ArY-substituted phenylalkynes. A highly selective cyclization controlled by heteroatoms

Authors :: Tatsuya Takachi
Shinjiro Kobayashi
Hiroshi Taniguchi
Tsugio Kitamura
Hironobu Kawasato
Source :: Tetrahedron Letters. 30:7445-7446
Publication Year :: 1989
Publisher :: Elsevier BV, 1989.
Abstract: Treatment of o-(phenyloxy)phenylalkyne 1 with HClO4 or HBF4 gave dibenz(b, f)oxepin 2, whereas the sulfur analogue, o-(phenylthio)phenylalkyne 3, provided 1-phenyl-1-benzothiophenium salts 4.

Subjects :: chemistry
Bicyclic molecule
Electrophilic addition
Organic Chemistry
Drug Discovery
Heteroatom
chemistry.chemical_element
Organic chemistry
Selectivity
Highly selective
Biochemistry
Sulfur
Medicinal chemistry

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