Efficient and Scalable Kinetic Resolution of Racemic 4-Formyl[2.2]paracyclophaneviaAsymmetric Transfer Hydrogenation

Herein we wish to report a new non-enzymatic kinetic resolution of racemic 4-formyl[2.2]paracyclophane based on Noyori asymmetric transfer hydrogenations (KR-ATH). Our approach, which provides an efficient access to enantiopure (Rp)- and (Sp)-4-formyl[2.2]paracyclophane (>99% ee, 39% and 41% isolated yields, respectively), is operationally simple and can be run on the gram-scale thus confirming the practical applicability of this method.