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Association between self-reported questionnaire data on fertility and results of hormone analyses in women after childhood cancer: A cross-sectional study
- Source :
- Journal of Obstetrics and Gynaecology Research. 38:1254-1259
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- Aim: The aim of this study was to compare self-reported questionnaire-based information on fertility impairment with results from hormone analyses in women who underwent chemoradiotherapy during childhood and adolescence. Material and Methods: In a cross-sectional study, questionnaires and hormone analyses (anti-Mullerian hormone [AMH], follicle-stimulating hormone, luteinizing hormone, estradiol, progesterone) were evaluated in 86 female former pediatric oncology patients in Berlin in 2009. Results: Eighty-six women (median age 23 years, range 19–41) participated in the study with a median follow up of 14 years (range 2–30) after diagnosis. Among women with information on permanent and transient amenorrhea, 9% (5/55) of the women stated that they were permanently amenorrheic. Among women not taking oral contraceptives and giving information on the regularity of their menstrual cycle, 18% (4/22) had an irregular menstrual cycle and 82% (18/22) had a regular menstrual cycle. The median AMH values for women who were categorized as infertile by questionnaire-based information were significantly lower than the AMH values of women who were categorized as fertile by questionnaire (0.05 vs 2.2 ng/mL, P = 0.004). Questionnaire-based categories on the regularity of the menstrual cycle and categories based on AMH values showed a satisfying percentage agreement (66.7%) and were moderately correlated (r = 0.42, P = 0.002). Conclusion: Self-reported questionnaire data used to detect fertility impairment has limited correspondence with objectively measured AMH values.
- Subjects :
- Gynecology
Infertility
medicine.medical_specialty
biology
business.industry
media_common.quotation_subject
Obstetrics and Gynecology
Anti-Müllerian hormone
Fertility
medicine.disease
Follicle-stimulating hormone
Median follow-up
medicine
biology.protein
Amenorrhea
medicine.symptom
business
Luteinizing hormone
Menstrual cycle
media_common
Subjects
Details
- ISSN :
- 13418076
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Journal of Obstetrics and Gynaecology Research
- Accession number :
- edsair.doi...........791c659d7fdd81f22bb4d9134fec217f