Anomalies in Structure of Teeth – Dentine

Developmental anomalies affecting the dentine are always genetic and heritable. They represent a group of diseases characterized by colour, shape, size and structure anomalies affecting the dentine but sometimes also the enamel. The full diagnosis is made through clinical and radiographic examination besides medical, dental and family history. They may sometimes be associated with other features in syndromes. One major gene DSPP has proven to be associated with dentinal defects restricted to the oral cavity therefore demonstrating that dentinogenesis imperfecta and dentine dysplasias are indeed allelic conditions. DSPP gene mutations have also been found in association with progressive hearing loss. Other syndromes, some of them related to collagen defects, encompass in their clinical features, dentine defects.