Back to Search
Start Over
Cardiac Scintigraphy With Technetium-99m-Labeled Bone-Seeking Tracers for Suspected Amyloidosis
- Source :
- Journal of the American College of Cardiology. 75:2851-2862
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Technetium-labeled cardiac scintigraphy (i.e., Tc-PYP scan) has been repurposed for the diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM). Validated in cohorts of patients with heart failure and echocardiographic and/or cardiac magnetic resonance imaging findings suggestive of cardiac amyloidosis, cardiac scintigraphy can confirm the diagnosis of ATTR-CM only when combined with blood and urine testing to exclude a monoclonal protein. Multisocietal guidelines support the nonbiopsy diagnosis of ATTR-CM using cardiac scintigraphy, yet emphasize its use in the appropriate clinical context and the crucial need to rule out light chain amyloid cardiomyopathy. Although increased awareness of ATTR-CM and the advent of effective therapy have led to rapid adoption of diagnostic scintigraphy, there is heterogeneity in adherence to consensus guidelines. This perspective outlines clinical scenarios wherein findings on technetium-labeled cardiac scintigraphy have been misinterpreted, reviews causes of false-negative and false-positive results, and provides strategies to avoid costly and potentially fatal misdiagnoses.
- Subjects :
- medicine.medical_specialty
medicine.diagnostic_test
business.industry
Amyloidosis
Cardiomyopathy
Context (language use)
030204 cardiovascular system & hematology
medicine.disease
Scintigraphy
03 medical and health sciences
0302 clinical medicine
Cardiac amyloidosis
Cardiac magnetic resonance imaging
Heart failure
medicine
030212 general & internal medicine
Radiology
Cardiology and Cardiovascular Medicine
Amyloid cardiomyopathy
business
Subjects
Details
- ISSN :
- 07351097
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Cardiology
- Accession number :
- edsair.doi...........7838b2a9f44f3eb4bff0d83e9bf11078