ChemInform Abstract: Optical Resolution of Ferrocene Derivatives by Liquid Chromatography Using Aqueous Cyclomaltohexaose as the Mobile Phase and Polyamide as the Stationary Phase

1-Ferrocenylethanol and its analogues were completely resolved into their enantiomers by liquid chromatography on a polyamide column using aqueous cyclomaltohexaose (α-cyclodextrin, αCD) as the mobile phase. The stability constants (K c ) for the inclusion complexes of αCD with each enantiomer of 1-ferrocenylethanol, determined by liquid chromatography with various concentrations of αCD, were for ( S )-ferrocenylethanol and for the ( R ) isomer. The temperature dependence of the resolution has been studied.