Synthesis of bis-Tetrahydroisoquinolines Based on Homoveratrylamine and Several Dibasic Acids. 4. Reaction with Malonic and Succinic Acids

Bischler–Napieralski cyclization of amides synthesized from homoveratrylamine and malonic and succinic acids produced N-(3,4-dimethoxy-β-phenylethyl)-succinimide, 1,1-bis-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)methane, cleavage products, and several intermediates, the structures of which were confirmed using IR and NMR spectral data and x-ray crystal structure analysis.