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Synthesis of conjugates of closo-dodecaborate dianion with cholesterol using a 'click' reaction
- Source :
- Russian Chemical Bulletin. 69:1080-1084
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- The nucleophilic ring-opening reaction of tetrahydropyran derivative of the closo-dode-caborate dianion with sodium azide in the presence of tetrabutylammonium bromide led to the novel azido-derivatives of[B12H12]2−. A Cu-catalyzed 1,3-dipolar [3+2] cycloaddition reaction of the closo-dodecaborate dianion azido-derivatives with alkynyl-cholesterol led to 1,4-disubstituted 1,2,3-triazoles with the closo-dodecaborate fragment at position 1. The resulting conjugates are potentially suitable for the development of liposomal drugs to selectively deliver boron into a tumor cell for boron neutron capture therapy of cancer.
- Subjects :
- inorganic chemicals
010405 organic chemistry
Chemistry
Dodecaborate
chemistry.chemical_element
General Chemistry
Tetrahydropyran
010402 general chemistry
01 natural sciences
Medicinal chemistry
Cycloaddition
0104 chemical sciences
chemistry.chemical_compound
Nucleophile
Click chemistry
Sodium azide
Boron
Derivative (chemistry)
Subjects
Details
- ISSN :
- 15739171 and 10665285
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Russian Chemical Bulletin
- Accession number :
- edsair.doi...........778b2b01f1f69c20be73c048684d2533