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Destruction of α-synuclein based amyloid fibrils by a low temperature plasma jet

Authors :
Erdinc Karakas
Agatha Munyanyi
Mounir Laroussi
Lesley H. Greene
Source :
Applied Physics Letters. 97:143702
Publication Year :
2010
Publisher :
AIP Publishing, 2010.

Abstract

Amyloid fibrils are ordered beta-sheet aggregates that are associated with a number of neurodegenerative diseases such as Alzheimer and Parkinson. At present, there is no cure for these progressive and debilitating diseases. Here we report initial studies that indicate that low temperature atmospheric pressure plasma can break amyloid fibrils into smaller units in vitro. The plasma was generated by the “plasma pencil,” a device capable of emitting a long, low temperature plasma plume/jet. This avenue of research may facilitate the development of a plasma-based medical treatment.

Details

ISSN :
10773118 and 00036951
Volume :
97
Database :
OpenAIRE
Journal :
Applied Physics Letters
Accession number :
edsair.doi...........77045af2312c4b9cd1be75a18888bd7e
Full Text :
https://doi.org/10.1063/1.3499277