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Factors Associated with the Change in Carotid Maximum Intima-Media Thickness in Patients with Moderate-to-Advanced Stage Chronic Kidney Disease
- Source :
- Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13:3637-3643
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- Purpose The objective of this study was to determine factors associated with the change in carotid maximum intima-media thickness (IMT), an established surrogate marker of atherosclerosis, in moderate-to-advanced stage chronic kidney disease (CKD) patients. Methods In total, 130 moderate-to-advanced stage CKD patients (mean age: 67.6 ± 11.0 years old; 91 men and 39 women) were included in this retrospective, single-center, observational study. Relationships between the change in carotid maximum IMT and clinical and laboratory data were analyzed by using multivariate linear regression analyses. Results Mean observation period was 2.9 ± 1.6 years. Mean carotid maximum IMT at baseline was 2.2 ± 1.0 mm, and the annual change in carotid maximum IMT was 0.06 ± 0.22 mm/year. Low-density lipoprotein (LDL)-cholesterol (β = 0.173, p < 0.05) and annual change in triglyceride (β = 0.175, p < 0.05) independently correlated with the annual change in carotid maximum IMT. Conclusion Increases in LDL-cholesterol and triglyceride were associated with the rate of progression of carotid maximum IMT in moderate-to-advanced stage CKD patients.
- Subjects :
- Pharmacology
medicine.medical_specialty
Triglyceride
business.industry
Surrogate endpoint
medicine.disease
chemistry.chemical_compound
chemistry
Intima-media thickness
Bayesian multivariate linear regression
Internal medicine
cardiovascular system
Internal Medicine
Cardiology
Medicine
In patient
cardiovascular diseases
Stage (cooking)
business
Kidney disease
Lipoprotein
Subjects
Details
- ISSN :
- 11787007
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
- Accession number :
- edsair.doi...........7639645a55708de563096043fbc5f391