Analysis of baseline characteristics by emphysema extent in patients with idiopathic pulmonary fibrosis (IPF)

Introduction: In an analysis of pooled data from the GIPF-001 (NCT00047645) and GIPF-007 (NCT00075998) trials of patients with IPF, emphysema extent ≥15% was associated with reduced forced vital capacity (FVC) decline vs no emphysema/emphysema Methods: 455 patients from GIPF-001 and GIPF-007 were stratified by baseline emphysema extent. Parameters collected included FVC, forced expiratory volume in 1 second (FEV 1 ), carbon monoxide diffusing capacity (DLco), University of California San Diego Shortness of Breath Questionnaire (UCSD-SOBQ) score and composite physiologic index (CPI). Results: Baseline parameters for patients stratified by emphysema extent are reported in the Table. Compared with patients with emphysema >0% to 1 /FVC (p 1 , DLco, FVC/DLco, UCSD-SOBQ or CPI. Conclusions: The results of this post-hoc analysis demonstrate differences in baseline characteristics in patients with IPF and emphysema ≥15% vs >0% to