Association of obesity with cytogenetic risk in adult acute myeloid leukemia (AML)

7055 Background: Obesity, body mass index (BMI) ≥30 kg/m2, is a risk factor for several malignancies. Prospective studies have reported a positive association between obesity and adult leukemia. The association between obesity and AML cytogenetic risk groups is unknown. We therefore evaluated a cohort of 295 AML patients with confirmed cytogenetics analysis diagnosed and treated at Mayo Clinic Florida and Arizona since 1995. Methods: Documented patient characteristics including height and weight, past medical history, medications, cytogenetics, treatments, and outcomes regarding their diagnosis of AML were extracted from a central electronic medical record. Standard cytogenetic risk categories (including intermediate abnormal) were applied. The association of obesity with cytogenetic risk was evaluated on multivariable analysis using logistic regression models. Results: The median BMI was 26.9 kg/m2 (range 16.9-59.9). 82 patients (28%) in the evaluated cohort were obese. On multivariable analysis obesity ...