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The synthesis of labelled forms of cipemastat
- Source :
- Journal of Labelled Compounds and Radiopharmaceuticals. 44:149-164
- Publication Year :
- 2001
- Publisher :
- Wiley, 2001.
-
Abstract
- The development of the collagenase inhibitor, cipemastat (Ro 32-3555), required the synthesis of both carbon-14 labelled and deuteriated material for the measurement of the parent drug and drug-related material in biological fluids. In addition, labelled metabolites were needed for both in vitro metabolism and analytical studies. This paper describes the synthesis of labelled forms of cipemastat and its amide (Ro 32-4778) and glucuronide (Ro 32-6414) metabolites. Copyright © 2001 John Wiley & Sons, Ltd.
- Subjects :
- chemistry.chemical_classification
Hydroxamic acid
biology
medicine.drug_class
Chemistry
Stereochemistry
Organic Chemistry
Carboxamide
Biochemistry
Chemical synthesis
Analytical Chemistry
chemistry.chemical_compound
Enzyme
Enzyme inhibitor
Amide
Drug Discovery
medicine
Cipemastat
biology.protein
Radiology, Nuclear Medicine and imaging
Glucuronide
Spectroscopy
Subjects
Details
- ISSN :
- 10991344 and 03624803
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Journal of Labelled Compounds and Radiopharmaceuticals
- Accession number :
- edsair.doi...........7540a226518c1c0484d13f50a9d47f8a