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Worse outcome of sorafenib therapy associated with ascites and Child-Pugh score in advanced hepatocellular carcinoma
- Source :
- Journal of Gastroenterology and Hepatology. 28:1756-1761
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- Background and Aim The outcomes of sorafenib therapy in patients with advanced hepatocellular carcinoma (HCC) and impaired liver function remain unresolved. Although Child–Pugh (CP) classification is widely used for patient categorization, heterogeneity within a given CP class makes outcomes less predictable. The aim was to investigate the prognostic significance of CP score elements on the outcome of sorafenib in patients with advanced HCC and impaired liver function. Methods Of 1385 consecutive patients with advanced HCC in our center between January 2007 and December 2010, we reviewed the medical records of 325 patients who received sorafenib monotherapy. Results Median duration of sorafenib was 2.0 months (range 0.4–24.2) and median follow-up was 4.9 months (range 0.5–43.4). Disease control rates were significantly higher in CP class A (CPA) than in CP class B (CPB) patients. Median overall survival (OS) was 5.8 months. Subgroups with different CP scores showed significantly different OS (months): CPA5, 8.4; CPA6, 5.1; CPB7, 3.5; CPB8–9, 2.6 (P
- Subjects :
- Sorafenib
medicine.medical_specialty
Hepatology
business.industry
Medical record
Child–Pugh score
Hazard ratio
Gastroenterology
Impaired liver function
medicine.disease
digestive system diseases
Surgery
Internal medicine
Hepatocellular carcinoma
Ascites
medicine
In patient
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 08159319
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Gastroenterology and Hepatology
- Accession number :
- edsair.doi...........74dff3f73c1cf85539b996c2ec6886d0