Near-infrared Spectroscopy in Cerebral Oxygenation Monitoring in Full-term Neonates During Transition: Prospective Cohort Study

BackgroundBrain is the most important organ in resuscitation. NIRS-measured cerebral oxygenation is evolving brain monitoring tool for neonatal resuscitation.MethodWe undertook a prospective observational study for monitoring of cerebral oxygenation and peripheral preductal saturation at 1 , 5 and 10 minutes after birth to establish centile chart normative for monitoring of full term neonates during transition. Fractional tissue oxygen extraction was calculated as well. In addition to studying factors affecting cerebral oxygenation at those points in time.Results 60 healthy term neonates were enrolled to define reference ranges and centile charts of cerebral oxygenation at 1, 5, and 10 minutes after birth. The strongest correlations between cerebral oxygenation metrics and peripheral preductal saturation were at 5 minutes after birth. The most significant factor affecting NIRS-measured crSO2 in healthy full term neonates was mode of delivery. This work was registered in the cinicaltrial.gov NCT05158881.Conclusions Normal references of cerebral oxygenation metrics can be used to guide intervention during neonatal resuscitation. Caesarean section is the most significant factor affecting cerebral oxygenation during the transition of healthy full term neonates.