Back to Search
Start Over
CAR, CRS und Neurotoxizität: schwere Komplikationen der Immuntherapie
- Source :
- Medizinische Klinik - Intensivmedizin und Notfallmedizin. 115:198-204
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Background The development of chimeric antigen receptor (CAR) T‑cells has shown promising results in relapsed/refractory B‑cell acute lymphoblastic leukemia/lymphoma (B-ALL) and diffuse large cell B‑cell lymphoma. Complications, especially cytokine release syndrome (CRS) and CAR T‑cell related encephalopathy syndrome (CRES), can be life threatening. The management of both plays a key role in CAR T‑cell therapy. Objectives Diagnosis, clinical presentation and development of complications in the treatment with CAR T‑cells. Materials and methods Summary of incidence, mortality and treatment of severe complications after administration of CAR T‑cells referring to current studies and therapy recommendations. Results Complications after administration of CAR T‑cells, especially CRS and CRES, can be life threatening. The timely identification of side effects and their appropriate treatment usually leads to complete recovery. Conclusions Using a therapy algorithm in the treatment with CAR T‑cells allows safe management of toxicities and can be helpful in recognizing them in time.
- Subjects :
- medicine.medical_specialty
business.industry
medicine.medical_treatment
Encephalopathy
Neurotoxicity
Immunotherapy
Emergency Nursing
Critical Care and Intensive Care Medicine
medicine.disease
Chimeric antigen receptor
Lymphoma
03 medical and health sciences
Cytokine release syndrome
chemistry.chemical_compound
0302 clinical medicine
Tocilizumab
chemistry
Refractory
Emergency Medicine
Internal Medicine
medicine
030212 general & internal medicine
Intensive care medicine
business
Subjects
Details
- ISSN :
- 21936226 and 21936218
- Volume :
- 115
- Database :
- OpenAIRE
- Journal :
- Medizinische Klinik - Intensivmedizin und Notfallmedizin
- Accession number :
- edsair.doi...........749cd091d269dc695acca992fbca9716