Evaluation of anxiolytic activity of embelin isolated from Embelia ribes

The study aimed to evaluate the anxiolytic activity of embelin that was isolated from Embelia ribes . It significantly increased the percentage of time spent and number of entries in open arm in elevated plus-maze apparatus. In light and dark model, embelin produced significant increase in time spent, number of crossing and decrease in the duration of immobility in light box. In open field test, embelin showed significant increase in number of rearing, assisted rearing and number of square crossed. On the basis of result, embelin showed its anxiolytic effect in dose-dependent manner.