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Novel Functions of the Septin Cytoskeleton
- Source :
- The American Journal of Pathology. 191:40-51
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Chronic inflammatory diseases cause profound alterations in tissue homeostasis, including unchecked activation of immune and nonimmune cells leading to disease complications such as aberrant tissue repair and fibrosis. Current anti-inflammatory therapies are often insufficient in preventing or reversing these complications. Remodeling of the intracellular cytoskeleton is critical for cell activation in inflamed and fibrotic tissues; however, the cytoskeleton has not been adequately explored as a therapeutic target in inflammation. Septins are GTP-binding proteins that self-assemble into higher order cytoskeletal structures. The septin cytoskeleton exhibits a number of critical cellular functions, including regulation of cell shape and polarity, cytokinesis, cell migration, vesicle trafficking, and receptor signaling. Surprisingly, little is known about the role of the septin cytoskeleton in inflammation. This article reviews emerging evidence implicating different septins in the regulation of host-pathogen interactions, immune cell functions, and tissue fibrosis. Targeting of the septin cytoskeleton as a potential future therapeutic intervention in human inflammatory and fibrotic diseases is also discussed.
- Subjects :
- 0301 basic medicine
Cell migration
macromolecular substances
Biology
medicine.disease
Septin
Pathology and Forensic Medicine
Cell biology
Extracellular matrix
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Fibrosis
medicine
Cytoskeleton
Cell activation
030217 neurology & neurosurgery
Tissue homeostasis
Septin cytoskeleton
Subjects
Details
- ISSN :
- 00029440
- Volume :
- 191
- Database :
- OpenAIRE
- Journal :
- The American Journal of Pathology
- Accession number :
- edsair.doi...........744cceaf2f7d5a91fa59b1e8e3b6adc9