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Effective cancer targeting and imaging using macrophage membrane-camouflaged upconversion nanoparticles
- Source :
- Journal of Biomedical Materials Research Part A. 105:521-530
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Upconversion nanoparticles (UCNPs), with fascinating optical and chemical features, are a promising new generation of fluorescent probes. Although UCNPs have been widely used in diagnosis and therapy, there is an unmet need for a simple and effective surface engineering method that can produce cancer-targeting UCNPs. Here, we show that by coating particles with macrophage membranes, it becomes possible to utilize the adhesion between macrophages and cancer cells for effective cancer targeting. Natural macrophage membranes along with their associated membrane proteins were reconstructed into vesicles and then coated onto synthetic UCNPs. The resulting macrophage membrane-camouflaged particles (MM-UCNPs) exhibited effective cancer targeting capability inherited from the source cells and were further used for enhanced in vivo cancer imaging. Finally, the blood biochemistry, hematology testing and histology analysis results suggested a good in vivo biocompatibility of MM-UCNPs. The combination of synthetic nanoparticles with biomimetic cell membranes embodies a novel design strategy toward developing biocompatible nanoprobes for potential clinical applications. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 521-530, 2017.
- Subjects :
- Materials science
Vesicle
Metals and Alloys
Biomedical Engineering
Nanoparticle
Nanotechnology
02 engineering and technology
Adhesion
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
0104 chemical sciences
Biomaterials
Membrane
Membrane protein
In vivo
Cancer cell
Ceramics and Composites
Macrophage
0210 nano-technology
Subjects
Details
- ISSN :
- 15493296
- Volume :
- 105
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedical Materials Research Part A
- Accession number :
- edsair.doi...........742f2def92e236195e4427f96d1d6242