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Iodization-enhanced fluorescence and circularly polarized luminescence for dual-readout probe design
- Source :
- Sensors and Actuators B: Chemical. 347:130610
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Circularly polarized luminescence (CPL) is a preferential emission from chiral systems. Introducing CPL to traditional small fluorescence probes will greatly enhance selectivity and sensitivity due to avoiding the background fluorescence. Small-molecule probes are practically useful for bioimaging and sensing but always suffer from weak CPL properties. To optimize chiral perturbation, the study of structure-CPL correlation is an urgent necessity. Here, we investigated the influence of 3, 3′-substituent of BINOL on optical properties and found that iodization could significantly enhance the fluorescence quantum yield (ΦF) and dissymmetry factor (|glum|). Based on this finding, we presented a strategy to design dual-readout probes emiting both robust total fluorescence and CPL upon activation. As an application example, we first designed a pair of thiols probes, R/S-P1, with the fluorescence readout showing good linear response to cysteine, and CPL signal displaying significant enhancement with |glum| from undetectable value to 0.7 × 10−3.
- Subjects :
- Background fluorescence
Materials science
business.industry
Metals and Alloys
Quantum yield
Condensed Matter Physics
Signal
Fluorescence
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Materials Chemistry
Optoelectronics
Electrical and Electronic Engineering
Luminescence
Selectivity
business
Instrumentation
Subjects
Details
- ISSN :
- 09254005
- Volume :
- 347
- Database :
- OpenAIRE
- Journal :
- Sensors and Actuators B: Chemical
- Accession number :
- edsair.doi...........740d7beed54f9ef7be98fca39ad81d3c