Sa1289 Culture-Independent Quantitation of Clostridium difficile in C57BL/6 Mice Aids Mechanistic Study of Disease Pathophysiology and Protective Immunology

was a hematopoietic stem cell transplant recipient patient who was found to have chronic graft-versus-host disease of the terminal ileum. FMT was aborted in this patient despite finding of persistent C. difficile PCR prior to attempted FMT. Two patients were found to have collagenous colitis, which had not been evident on colonoscopies performed within a year of FMT. One patient was found to have a 1.5 cm tubulovillous adenoma. Conclusions: No significant differences in response or AE were seen when comparing UGI tract versus colonoscopy method of FMT delivery as well immunocompromised versus nonimmunocompromised patients. Most patients prefer using a standard donor over a relative. FMT using colonoscopy may help to identify additional pathology that may not be evident when using other modes of delivery. Table 1. Comparison of FMT performed using upper gastrointestinal tract* versus colonoscopy