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Comparison of Functional Free-Breathing Pulmonary 1H and Hyperpolarized 129Xe Magnetic Resonance Imaging in Pediatric Cystic Fibrosis

Authors :
Giles E. Santyr
Jens Vogel-Claussen
Andreas Voskrebenzev
Jonathan H. Rayment
Samal Munidasa
Marcus J. Couch
Felix Ratjen
Ravi Teja Seethamraju
Source :
Academic Radiology. 28:e209-e218
Publication Year :
2021
Publisher :
Elsevier BV, 2021.

Abstract

Rationale and Objectives Phase resolved functional lung (PREFUL) magnetic resonance imaging (MRI) is a free-breathing 1H-based technique that produces maps of fractional ventilation (FV). This study compared ventilation defect percent (VDP) calculated using PREFUL to hyperpolarized (HP) 129Xe MRI and pulmonary function tests in pediatric cystic fibrosis (CF). Materials and Methods 27 pediatric participants were recruited (mean age 13.0 ± 2.7), including 6 with clinically stable CF, 11 CF patients undergoing a pulmonary exacerbation (PEx), and 10 healthy controls. Spirometry was performed to measure forced expiratory volume in 1 second (FEV1), along with nitrogen multiple breath washout to measure lung clearance index (LCI). VDP was calculated from single central coronal slice PREFUL FV maps and the corresponding HP 129Xe slice. Results The stable CF group had a normal FEV1 (p = 0.41) and elevated LCI (p = 0.007). The CF PEx group had a decreased FEV1 (p Conclusion PREFUL MRI is feasible in pediatric CF, distinguishes patients undergoing pulmonary exacerbations compared to healthy subjects, and correlates with HP 129Xe MRI as well as functional measures of disease severity. PREFUL MRI does not require breath-holds and is straight forward to implement on any MRI scanner.

Details

ISSN :
10766332
Volume :
28
Database :
OpenAIRE
Journal :
Academic Radiology
Accession number :
edsair.doi...........73d23b2951002d9756ab11c86fe1d89e
Full Text :
https://doi.org/10.1016/j.acra.2020.05.008