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Comparison of Functional Free-Breathing Pulmonary 1H and Hyperpolarized 129Xe Magnetic Resonance Imaging in Pediatric Cystic Fibrosis
- Source :
- Academic Radiology. 28:e209-e218
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Rationale and Objectives Phase resolved functional lung (PREFUL) magnetic resonance imaging (MRI) is a free-breathing 1H-based technique that produces maps of fractional ventilation (FV). This study compared ventilation defect percent (VDP) calculated using PREFUL to hyperpolarized (HP) 129Xe MRI and pulmonary function tests in pediatric cystic fibrosis (CF). Materials and Methods 27 pediatric participants were recruited (mean age 13.0 ± 2.7), including 6 with clinically stable CF, 11 CF patients undergoing a pulmonary exacerbation (PEx), and 10 healthy controls. Spirometry was performed to measure forced expiratory volume in 1 second (FEV1), along with nitrogen multiple breath washout to measure lung clearance index (LCI). VDP was calculated from single central coronal slice PREFUL FV maps and the corresponding HP 129Xe slice. Results The stable CF group had a normal FEV1 (p = 0.41) and elevated LCI (p = 0.007). The CF PEx group had a decreased FEV1 (p Conclusion PREFUL MRI is feasible in pediatric CF, distinguishes patients undergoing pulmonary exacerbations compared to healthy subjects, and correlates with HP 129Xe MRI as well as functional measures of disease severity. PREFUL MRI does not require breath-holds and is straight forward to implement on any MRI scanner.
- Subjects :
- Spirometry
Lung
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
Lung Clearance Index
medicine.disease
Cystic fibrosis
030218 nuclear medicine & medical imaging
Pulmonary function testing
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
030220 oncology & carcinogenesis
Coronal plane
Breathing
Medicine
Radiology, Nuclear Medicine and imaging
business
Nuclear medicine
Subjects
Details
- ISSN :
- 10766332
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Academic Radiology
- Accession number :
- edsair.doi...........73d23b2951002d9756ab11c86fe1d89e
- Full Text :
- https://doi.org/10.1016/j.acra.2020.05.008