PC.120 Relationship between EEG and continuously measured invasive blood pressure in extremely preterm infants in the first three days of life

Introduction Electroencephalographic activity may be influenced by several factors including the gestation of the infant, blood pressure (BP) and inotropic support.1 However, previous studies have used a mixture of invasive and non-invasive BP measurements. We hypothesised that increasing BP and gestation is associated with increased electroencephalographic activity. Methods Infants born Results In 18 subjects, mean (range) gestation and birth weight were 25.4 (23–28) weeks and 756 (515–1070) grams respectively. At most time points after 12 h BP was positively associated with aEEG activity with a stronger association than gestation. At 0–12 h, babies on inotropes had significantly lower aEEG activity (p = 0.013), with no evidence of gestation or BP having an effect. Conclusions There was an association between continuously measured invasive BP and aEEG activity at most time points. However, at 0–12 h we found aEEG activity was lower in babies receiving inotropic support. Reference Shah D, Paradisis M, Bowen JR. Relationship between systemic blood flow, blood pressure, inotropes, and aEEG in the first 48 h of life in extremely preterm infants. Pediatric Research 2013