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1410 EFFECT OF PROSTAGLANDIN SYNTIIETASE INHIBITION ON FETAL AND MEONATAL ALVEOLAR PHOSPHOLIPIDS
1410 EFFECT OF PROSTAGLANDIN SYNTIIETASE INHIBITION ON FETAL AND MEONATAL ALVEOLAR PHOSPHOLIPIDS
- Source :
- Pediatric Research. 15:678-678
- Publication Year :
- 1981
- Publisher :
- Springer Science and Business Media LLC, 1981.
-
Abstract
- The effect of prenatally administered Indomethacin (Indo), a prostaglandin synthetase inhibitor, on alveolar disaturated phosphotidylcholine (DSPC) in the fetal and neonatal rabbit was studied. Pregnant rabbits were injected S.C. with either 0.01 M Na2CO3 or 3 mg/kg Indo in 0.01 M Na2CO3 b.i.d. from 27 through 29 days of gestation inclusive (3 day group). Fetuses were sacrificed on day 30 and the lungs washed with 0.9% NaCl. Newborn pups were delivered and allowed to breathe air for either 0.5 or 1.0 hours and then lung washes obtained. Pregnant does were also given Indo (3 mg/kg b.i.d.) or Na2CO3 on day 29 and fetal lung washes obtained on day 30 (1 day group). Results: Thus during fetal life alveolar DSPC was halved by Indo by 24 hrs but doubled by 3 d. In the pups given 3 d of Indo prior to delivery alveolar DSPC was increased by 54% at 0.5 hrs air breathing but there was no effect by 1 hr. We postulate that Indo temporarily decreases fetal lung surfactant release but that fetal breathing activity is more important in determining release than prostaglandins. Furthermore, Indo does not inhibit the massive release associated with the onset of air breathing.
- Subjects :
- Fetus
medicine.medical_specialty
Lung
business.industry
digestive, oral, and skin physiology
Prostaglandin
chemistry.chemical_compound
Endocrinology
medicine.anatomical_structure
Pulmonary surfactant
chemistry
Internal medicine
Pediatrics, Perinatology and Child Health
medicine
Gestation
Fetal breathing
Fetal lung
business
Air breathing
Subjects
Details
- ISSN :
- 15300447 and 00313998
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Pediatric Research
- Accession number :
- edsair.doi...........73619061a9172763bb70b90052a46287
- Full Text :
- https://doi.org/10.1203/00006450-198104001-01439