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1410 EFFECT OF PROSTAGLANDIN SYNTIIETASE INHIBITION ON FETAL AND MEONATAL ALVEOLAR PHOSPHOLIPIDS

1410 EFFECT OF PROSTAGLANDIN SYNTIIETASE INHIBITION ON FETAL AND MEONATAL ALVEOLAR PHOSPHOLIPIDS

Authors :
Brian J Russell
Victor Chernick
Glenda Gandza
Source :
Pediatric Research. 15:678-678
Publication Year :
1981
Publisher :
Springer Science and Business Media LLC, 1981.

Abstract

The effect of prenatally administered Indomethacin (Indo), a prostaglandin synthetase inhibitor, on alveolar disaturated phosphotidylcholine (DSPC) in the fetal and neonatal rabbit was studied. Pregnant rabbits were injected S.C. with either 0.01 M Na2CO3 or 3 mg/kg Indo in 0.01 M Na2CO3 b.i.d. from 27 through 29 days of gestation inclusive (3 day group). Fetuses were sacrificed on day 30 and the lungs washed with 0.9% NaCl. Newborn pups were delivered and allowed to breathe air for either 0.5 or 1.0 hours and then lung washes obtained. Pregnant does were also given Indo (3 mg/kg b.i.d.) or Na2CO3 on day 29 and fetal lung washes obtained on day 30 (1 day group). Results: Thus during fetal life alveolar DSPC was halved by Indo by 24 hrs but doubled by 3 d. In the pups given 3 d of Indo prior to delivery alveolar DSPC was increased by 54% at 0.5 hrs air breathing but there was no effect by 1 hr. We postulate that Indo temporarily decreases fetal lung surfactant release but that fetal breathing activity is more important in determining release than prostaglandins. Furthermore, Indo does not inhibit the massive release associated with the onset of air breathing.

Details

ISSN :
15300447 and 00313998
Volume :
15
Database :
OpenAIRE
Journal :
Pediatric Research
Accession number :
edsair.doi...........73619061a9172763bb70b90052a46287
Full Text :
https://doi.org/10.1203/00006450-198104001-01439