Bone and Soft Tissue

A wide variety of bone and soft tissue lesions are seen in the pediatric population, including benign and malignant neoplasms, as well non-neoplastic processes. Fine needle aspiration and/or small biopsies are increasingly used for evaluating these lesions and in many cases, allow definitive diagnosis or a narrowed differential diagnosis on which to base treatment. This chapter describes the cytologic features of a number of common and uncommon neoplastic and non-neoplastic lesions of bone and soft tissue seen in the pediatric population, as well as key clinical and radiographic features of those entities and differential diagnostic considerations.