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Vaccination preventsHelicobacter pylori-induced alterations of the gastric flora in mice
- Source :
- FEMS Immunology & Medical Microbiology. 46:221-229
- Publication Year :
- 2006
- Publisher :
- Oxford University Press (OUP), 2006.
-
Abstract
- Molecular analysis of the gastric microflora in mice revealed that Helicobacter pylori infection causes an increase in microbial diversity. The stomachs of H. pylori-infected animals were colonized by bacteria which are naturally restricted to the lower intestinal tract. Clostridia, Bacteroides/Prevotella spp., Eubacterium spp., Ruminococcus spp., streptococci and Escherichia coli were detected exclusively in the stomachs of infected animals, whereas lactobacilli dominated the gastric flora in noninfected mice. The H. pylori-induced shifts in the gastric microbiota were independent from histological pathology and from changes in the gastric pH but were prevented by immunization of mice with live Salmonella expressing H. pylori urease. Immunized mice displayed reduced H. pylori levels in the gastric epithelium and developed a normal gastric microflora, indicating that vaccination may be protective against H. pylori-induced changes in the gastric flora.
- Subjects :
- Microbiology (medical)
biology
Ruminococcus
Spirillaceae
digestive, oral, and skin physiology
Immunology
General Medicine
Helicobacter pylori
medicine.disease_cause
biology.organism_classification
medicine.disease
Microbiology
digestive system diseases
Infectious Diseases
medicine
Prevotella
Immunology and Allergy
Eubacterium
Bacteroides
Stomach cancer
Escherichia coli
Subjects
Details
- ISSN :
- 1574695X and 09288244
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- FEMS Immunology & Medical Microbiology
- Accession number :
- edsair.doi...........734f3e45ac0d9ea5e0c841d838b9e774