The Cytomorphological Effects of L-Asparaginase in Sensitive Cells

This report is concerned with light microscopic and, especially, electron microscopic changes taking place under the influence of Crasnitin 1 in laboratory animals and in vitro. The only morphological findings so far available are those of Borella et al. (1966) on ascitic cells in a case of lymphosarcoma. The guinea-pig-L-asparaginase which they used failed to produce significant effects on the lymphosarcoma cells examined. Our studies of the morphological pattern were intended to provide insight into the possible mechanism by which L-asparaginase acts on cells and tissues.