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Salivary immunity in elderly individuals presented with Candida-related denture stomatitis
- Source :
- Gerodontology. 29:e331-e339
- Publication Year :
- 2011
- Publisher :
- Wiley, 2011.
-
Abstract
- doi: 10.1111/j.1741-2358.2011.00476.x Salivary immunity in elderly individuals presented with Candida-related denture stomatitis Objectives: Elderly individuals with Candida-related denture stomatitis (DS) present with a reduced defence against Candida albicans. This study evaluated levels of antimicrobial mediators in the elderly DS saliva and salivary neutrophils’ activation characteristics compared with elderly and young without DS. Methods: Salivary peroxidases (SPO) and elastase activities (ELA), nitric oxide (NO), transforming growth factor beta (TGF-β), IL-6 and CCL3 production were determined in saliva from elderly with or without DS, and young control individuals. TLR4, CXCR1, CD11b, CD16 and CD32 expression on salivary neutrophils were evaluated. Correlations between number and apoptosis rate of salivary neutrophils, enzymatic activities and cytokine levels were determined. Results: Elderly DS individuals exhibited the lowest SPO and ELA activities. Also, the activity of both enzymes was low in elderly without DS. Although both elderly groups showed higher salivary NO and TGF-β levels compared to young control groups, elderly DS presented the highest salivary NO, TGF-β, IL-6 and CCL3 levels. Decreased percentages of salivary TLR4+ and CD16+ neutrophils were detected in both elderly groups. Although these damages could influence the establishment and persistence of DS, the highest levels of salivary IL-6 and CCL3 in elderly DS could be preventing more serious complications.
- Subjects :
- Saliva
biology
business.industry
medicine.medical_treatment
Elastase
social sciences
CD16
medicine.disease
biology.organism_classification
humanities
Nitric oxide
chemistry.chemical_compound
Cytokine
chemistry
Immunity
Immunology
Medicine
Geriatrics and Gerontology
business
Candida albicans
General Dentistry
Stomatitis
Subjects
Details
- ISSN :
- 07340664 and 17412358
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Gerodontology
- Accession number :
- edsair.doi...........7320e4d52585d84e189a72c39323e1dc