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Mo1825 Membrane Protein CD44v6 Is Not Expressed in Gastric Intestinal Metaplasia in a Sample of Helicobacter pylori Dyspeptic Adult Patients

Authors :
Carlos Fernando de Magalhães Francesconi
Luiz Edmundo Mazzoleni
Guilherme Becker Sander
Tobias Cancian Milbradt
Diego de Mendonça Uchôa
Ronaldo J. Torresini
Vinicius Duval da Silva
Luise Meurer
João Carlos Prolla
Source :
Gastroenterology. 146:S-663
Publication Year :
2014
Publisher :
Elsevier BV, 2014.

Abstract

was categorized as "negative" or "positive" or "eradicated". The study patients were categorized according to the presence of inlet patch as follows: group A, inlet patch positive; group B, inlet patch negative. Intergroup male-to-female ratios, H. pylori infection rate, and the prevalence of gastrointestinal diseases were compared using the Chi square test. Result: The baseline clinical characteristics are shown in Table 1. A total of 487 patients (237 females and 250 males, mean age 53.7 years) were examined. Of these, 47 patients (9.4%) were inlet patch positive (Group A), and 440 patients were inlet patch negative (Group B). The male-to-female ratio was significantly higher in group A than group B. Mean age was not statistically different in group A and group B. The prevalence of gastric atrophy, reflux esophagitis, esophageal hiatal hernia, and Barrett's esophagus were not different in group A and group B. The 47 inlet patches were pathologically examined, and the histological features were inactive atrophic fundic mucosa with mild to moderate mucus neck cell or pyloric gland cell metaplasia and no intestinal metaplasia except one case with H. pylori infection. Conclusion: Endoscopic detection rate of inlet patch was 9.4%. Male gender was risk factor for inlet patch. Pathological characteristics of inlet patch was mostly inactive fundic gastritis with (pseudo) pyloric gland metaplasia.

Details

ISSN :
00165085
Volume :
146
Database :
OpenAIRE
Journal :
Gastroenterology
Accession number :
edsair.doi...........730e93626f89a5fa14dd13695b977770
Full Text :
https://doi.org/10.1016/s0016-5085(14)62416-1