Synthesis and Antiproliferative and Antimicrobial Activity of Methyl-6-Amino-3-Acyl-4-Aryl-5-Cyano-4H-Pyran-2-Carboxylates and their Derivatives

Antiproliferative and antimicrobial activity of methyl-6-amino-3-acyl-4-aryl-5-cyano-4H-pyran-2-carboxylates and their analogs that were synthesized from methyl-2,4-dioxobutanoates was studied. Studies of their antiproliferative activity at the USA National Cancer Institute under the program NCI 60 Cell One-Dose Screen found that methyl-6-amino-5-cyano-4-(furan-2-yl)-3-(3-methoxybenzoyl)-4H-pyran-2-carboxylate had the highest activity, greater than those of busulfan and cisplatin. Methyl-6-amino-3-acetyl-4-phenyl-5-cyano-4H-pyran-2-carboxylate had antimicrobial activity that was comparable with that of chloramine.